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Jump to Key Points Oct 7 (Reuters) - Glaukos said on Wednesday patients treated with its late-stage eye disease therapy maintained improvements in vision and corneal shape three years after a single treatment for keratoconus, a disease that can progressively distort vision.
• The medtech firm said patients who received a single Epioxa treatment did not require additional intervention during the three-year follow-up period.
• Epioxa-treated eyes showed a 1.9-diopter improvement in maximum corneal curvature from baseline after three years, indicating sustained flattening and stabilization of the cornea.
• About 29% of Epioxa-treated eyes gained two or more lines on a standard vision chart, while 20% gained three or more lines from baseline.
- Single Epioxa dose maintained vision/corneal gains at 3 years in keratoconus.
- No additional intervention needed during 3-year follow-up.
- Max corneal curvature improved 1.9 D from baseline; sustained corneal flattening.
- 29% gained ≥2 lines; 20% gained ≥3 lines on vision chart.
- No serious, treatment-related AEs or discontinuations; 92% completed 3-year assessment.
• The results add to evidence supporting Epioxa, which was approved as a less invasive option for keratoconus because it does not require removal of the cornea's outer protective layer before treatment.
• The study included 38 eyes from 35 patients, and 92% of treated eyes completed the three-year assessment.
• Glaukos said there were no serious adverse events, treatment-related adverse events or treatment discontinuations linked to Epioxa during the follow-up period.
• Keratoconus typically begins in adolescence or early adulthood and can lead to worsening vision and, in severe cases, the need for a corneal transplant, according to Glaukos.
(Reporting by Sahil Pandey in Bengaluru)
