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3rd Feb, 2026 12:00 AM
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Pfizer's Experimental Drug Shows Up to 12.3% Weight Loss in Mid-stage Trial

Feb 3 (Reuters) - Pfizer said on Tuesday its experimental obesity drug, ‌which it acquired through the Metsera deal, showed up to ⁠12.3% weight loss in patients without diabetes in ‌a mid-stage trial.

In November, Pfizer acquired Metsera for up to $10 billion following a fierce bidding war with Novo Nordisk. 

The mid-stage trial was studying the monthly maintenance dosing ⁠of the drug, PF’3944, to see ​if it ⁠could achieve continued weight loss when switching from weekly to monthly injections under ‌the skin.

These data show ‌robust and ​continuous weight loss ‌after switching to monthly dosing, with no plateau observed at week 28, the company said, adding that it ​expects the trend to continue ​as ⁠the study reaches week 64.

Across both arms, five total participants ‍discontinued from treatment due to side effects in the weekly phase and five ‌total participants discontinued in the monthly ​phase.

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(Reporting by Sriparna Roy in Bengaluru; Editing by Leroy Leo)


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