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TOPLINE
Both active and passive smoke exposure were associated with increased odds of a hidradenitis suppurativa (HS) diagnosis in children and adolescents, according to a study. Passive smoke accounted for nearly two thirds of all smoke exposure.
METHODOLOGY
- Researchers conducted a retrospective case-control study at Mayo Clinic in Rochester, Minnesota, from 2010 to 2023 and included 174 patients diagnosed with HS before age 18 years.
- The mean age of participants was 14.3 years, and 85.6% of participants were female and 67.8% were White.
- They also assessed 522 healthy individuals matched 1:3 by age at diagnosis, sex, and race.
- Smoke exposure was categorized as none, passive, or active based on pre-visit questionnaires and medical records.
TAKEAWAY
- The prevalence of smoke exposure (active or passive) was significantly higher among patients with HS than among healthy individuals (27.6% vs 15.3%; P < .001). Both active (9.8% vs 3.6%; P = .002) and passive (17.8% vs 11.7%; P = .039) smoke exposure were more prevalent among patients with HS.
- Passive smoke accounted for 64.6% of all smoke exposure among those with HS.
- Active and/or passive smoke exposure was associated with higher odds of an HS diagnosis (odds ratio [OR], 4.82; 95% CI, 3.06-7.61). Active (OR, 2.87; 95% CI, 1.44-5.66) and passive (OR, 1.64; 95% CI, 1.01-2.61) smoke exposure were each associated with higher odds of an HS diagnosis.
- Among patients with HS, those with smoke exposure were diagnosed at an older age than those without smoke exposure.
IN PRACTICE
"This study demonstrates a correlation between passive and active smoke exposure in pediatric and adolescent patients with HS as compared to healthy controls of similar age, sex, and race," the authors wrote. "Holistic care should focus on limiting passive and active smoke exposure in pediatric and adolescent patients with HS, and counseling on the risk of passive smoke should be emphasized to parents and caregivers who smoke."
SOURCE
The study was led by Rachel L. Ziebart, Mayo Clinic Alix School of Medicine, Rochester. It was published online on September 9 in Pediatric Dermatology.
LIMITATIONS
The study relied on questionnaires, which prevented quantification of smoke exposure or assessment of a dose-dependent relationship. Other limitations included recall bias, retrospective design, and smaller sample size.
DISCLOSURES
This study was supported by grants from the National Institutes of Health and National Institute of General Medical Sciences. Two authors reported receiving consultation fees from AbbVie, Boehringer Ingelheim, InflaRx, and Mosaic Research Management. The remaining authors reported having no relevant conflicts of interest.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
