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TOPLINE:

Diet-induced inflammation is associated with a higher risk for fatty pancreas in patients with common bile duct stones, as confirmed by analyses using multiple dietary inflammatory indices.

METHODOLOGY:

• Fatty pancreas may be an early manifestation of metabolic syndrome and is linked to an increased risk for type 2 diabetes and pancreatic cancer.
• In this case-control study conducted in Iran from July 2022 to May 2023, researchers assessed 278 adult patients with common bile duct stones to examine the association between dietary inflammatory and fatty pancreas.
• Patients were categorized based on endoscopic ultrasound findings into those with fatty pancreas (n = 89; mean age, 56.9 years; 41% men) and those without (n = 189; mean age, 55.2 years; 59% men).
• Dietary intake was assessed using a validated 168-item semiquantitative food frequency questionnaire.
• The dietary inflammatory index (DII) and empirical dietary inflammatory pattern (EDIP) were used to assess dietary contributions to inflammation, and the dietary inflammatory score (DIS) to quantify lifestyle contributions, with comparisons made across tertiles.

TAKEAWAY:

• Higher DII scores were linked to a significantly increased risk for fatty pancreas (tertile 3 vs 1: adjusted odds ratio [aOR], 3.3; P for trend = .001).
• Similarly, higher EDIP and DIS scores (tertile 3 vs 1) were associated with a significantly increased risk for fatty pancreas (aOR, 2.5; P for trend = .009 and aOR, 2; P for trend = .040, respectively).

IN PRACTICE:

“The findings of the present study showed that higher scores of DII, EDIP and DIS were significantly associated with higher risk of fatty pancreas,” the authors wrote.

SOURCE:

This study was led by Maedeh Chegini, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. It was published online in Scientific Reports.

LIMITATIONS:

As a case-control study, the findings are subject to recall and selection bias. Dietary data were self-reported, which may have introduced inaccuracies. The study focused solely on patients with common bile duct stones, limiting generalizability.

DISCLOSURES:

The authors reported having no specific funding and declared no conflicts of interest.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.